Antigen Specificity in Experimental Bovine Tuberculosis

Antigen specificity in experimental bovine tuberculosis.

This report describes the kinetics of T-cell responses to a panel of mycobacterial antigens (PPD-M, PPD-A, ESAT-6, Ag85, 38kD, MPB64, MPB70, MPB83, hsp16.1, hsp65, and hsp70) following experimental infection of cattle with Mycobacterium bovis. Increased antigen-specific lymphocyte proliferation, gamma interferon, and interleukin-2 responses were observed in all calves following infection. Posit...

Diversity of antigen recognition by serum antibodies in experimental bovine tuberculosis.

Tuberculosis in cattle remains a major zoonotic and economic problem in many countries. The standard diagnostic assay for bovine tuberculosis, the intradermal tuberculin test, has low accuracy. Therefore, alternative immunodiagnostic methods, such as serological assays, are needed for detection of infected animals. Development of an accurate serodiagnostic test requires a detailed understanding...

Significance of Antigen and Epitope Specificity in Tuberculosis

Tuberculosis (TB) remains a major global health problem, because (i) diagnosis is usually made too late to avoid spread of infection to contacts; (ii) vaccination with bacillus Calmette–Guérin (BCG) does not prevent the most prevalent pulmonary disease; and (iii) defaulting from lengthy chemotherapy leads to an increase in drug resistant strains. The continued impact of human immunodeficiency v...

Frequency of Bovine Lymphocyte Antigen DRB3.2 Alleles in Sarabi Cows

Prevalence of bovine tuberculosis in zoo animals in Pakistan

The study was carried out in zoo animals at Islamabad Zoo, Pakistan to know the prevalence of bovinetuberculosis. An overall prevalence of 3.3% was recorded in zoo animals with 3.6% in Bovidae, 3.2% inCervidae and 0% in Equidae families. The positive animals included spotted deer (1/3; 95% CI = 0.84,90.57), Chinkara gazella (1/5; 95% CI = 0.51, 71.64) and Blackbuck gazelle (1/30; 95% CI = 0.08,...